Metascience
Latest Publication
August 29th 2025
American Science Should Take a Lot More Risks
Scientific efficiency isn’t primarily about the dollars we could save; it’s about the breakthroughs we could be missing
Read the full report
Emerging Technology
Preparing for Launch
An introduction to The Launch Sequence: Why shaping AI progress matters, and how to go about it
Read the full report
Emerging Technology
Teaching AI How Science Actually Works
How block-grant labs can generate the real-world data AI needs to do science
Read the full report
Emerging Technology
Using X-Labs to Unleash AI-Driven Scientific Breakthroughs
How to adapt our science funding mechanisms to the unique infrastructure needs of large-scale AI projects
Read the full report
Emerging Technology
The Replication Engine
How to build automated replication infrastructure for better, faster science
Read the full report
Emerging Technology
Benchmarking for Breakthroughs
How to incentivize AI for national priorities through a strategic challenge and evaluations program
Read the full report
Emerging Technology
Scaling Materials Discovery with Self-Driving Labs
How to close the gap between AI-guided material design and real-world validation
Read the full report
Emerging Technology
A Million-Peptide Database to Defeat Antibiotic Resistance
How to build a large peptides database to train the AlphaFold for new antibiotics
Read the full report
Emerging Technology
Faster AI Diffusion Through Hardware-Based Verification
How to use privacy-preserving verification in the AI hardware stack to build trust and limit misuse
Read the full report
Emerging Technology
Operation Patchlight
How to leverage advanced AI to give defenders an asymmetric advantage in cybersecurity
Read the full report
Emerging Technology
A Sprint Toward Security Level 5
How to protect American AI from nation-state level threats
Read the full report
Emerging Technology
Preventing AI Sleeper Agents
How to ensure American AI models are robust and reliable via a DOD-led red- and blue-teaming effort
Read the full report
Emerging Technology
The Infinity Project
How to use AI and mathematics to prove and improve science and security
Read the full report
Emerging Technology
Biotech’s Lost Archive
How to fuel AI by unlocking the FDA’s knowledge of biotech failures
Read the full report
Emerging Technology
Scaling Pathogen Detection with Metagenomics
How to generate the data necessary to reliably detect new pathogen outbreaks with AI
Read the full report
Emerging Technology
The Great Refactor
How to secure critical open-source code against memory safety exploits by automating code hardening at scale
Read the full report
