Infrastructure
Latest Publication
June 17th 2026
Stop Paying More for Less Transit
Fifteen ideas to bring costs down and speed projects up
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Emerging Technology
The Replication Engine
How to build automated replication infrastructure for better, faster science
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Emerging Technology
Benchmarking for Breakthroughs
How to incentivize AI for national priorities through a strategic challenge and evaluations program
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Emerging Technology
Scaling Materials Discovery with Self-Driving Labs
How to close the gap between AI-guided material design and real-world validation
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Emerging Technology
A Million-Peptide Database to Defeat Antibiotic Resistance
How to build a large peptides database to train the AlphaFold for new antibiotics
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Emerging Technology
Faster AI Diffusion Through Hardware-Based Verification
How to use privacy-preserving verification in the AI hardware stack to build trust and limit misuse
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Emerging Technology
Operation Patchlight
How to leverage advanced AI to give defenders an asymmetric advantage in cybersecurity
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Emerging Technology
A Sprint Toward Security Level 5
How to protect American AI from nation-state level threats
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Emerging Technology
Preventing AI Sleeper Agents
How to ensure American AI models are robust and reliable via a DOD-led red- and blue-teaming effort
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Emerging Technology
The Infinity Project
How to use AI and mathematics to prove and improve science and security
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Emerging Technology
Biotech’s Lost Archive
How to fuel AI by unlocking the FDA’s knowledge of biotech failures
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Emerging Technology
Scaling Pathogen Detection with Metagenomics
How to generate the data necessary to reliably detect new pathogen outbreaks with AI
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Emerging Technology
The Great Refactor
How to secure critical open-source code against memory safety exploits by automating code hardening at scale
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Emerging Technology
Mapping the Brain for Alignment
How to map the mammalian brain’s connectome to solve fundamental problems in neuroscience, psychology, and AI robustness
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Metascience
Indirect Cost Recovery and American Innovation: Context and Ideas for Reform
How the government covers indirect costs directly affects scientific innovation
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Infrastructure
Climate Activists Need to Radically Change Their Approach Under Trump
Climate advocates must double down on pragmatic industrial strategies to make clean energy a winning business for all
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